Aloperine impact on immune function includes inhibitory effect on macrophages, resulting in reduction of IL-1 production. It has a similar effect on IL-2 production in mice spleen cells.
**Keywords**: Aloperine, IL-1, IL-2, Lymphocyte proliferation
### Nitroglycerin on Hemodynamics and Clinical Significance in Senile Patients with Liver Cirrhosis
#### Jilin Province People's Hospital: Guo Hanging, Qin Yang, Xiaoling Adjoint
Also known as '1' data and methods:
1. **Detect Objects**: Outpatient and hospitalized elderly patients with cirrhosis (36 cases). Male, mean age 62 ± 7.5 years. Detailed reviews (imaging, blood biochemistry, etc.) according to the Child-Pugh classification factors. Divided into A, B, C, three groups with 12 cases each.
2. **Apparatus and Method**: Application of ATLu-g color Doppler ultrasonic diagnostic apparatus. Convex probe, frequency of 3.5 MHz. Subjects, 3 days before the test, discontinue all hemodynamic drugs, blood transfusion, and infusion. Check fasting for 8~12 hours. First, detect the underlying portal vein blood flow indicators as controls, including inner diameter (Dpv), blood flow speed (Vpv), blood flow (FPV), measured by mean arterial pressure (MBp) and heart rate (HR).
Then give the patients NG 0.5 mg sublingual at 10, 20, and 30 minutes, in the same position, repeat testing three times, averaging records.
### Results:
1. After sublingual NG 0.5 mg, the patients Dpv at all levels are mildly dilated, but with no significant difference before treatment (P > 0.05). Class A and B patients at 10 and 20 minutes showed significantly reduced Dpv and Fpv compared to before treatment with a significant difference (P 0.05) showed no significant differences.
2. Sublingual NG within 30 minutes. Fpv fell on average A-level by 16.1 (P < 0.05). Within 30 minutes post-treatment, the vein trunk blood flow decreased by 10.92, mean arterial blood pressure decreased by 15.86. Statistical linear correlation analysis showed a highly positive (y = 0.77), average heart rate increased by 17.63, showing a significant difference compared with before treatment (P < 0.001).
### Discussion:
The use of drugs to reduce portal resistance and decrease vein blood flow to achieve prevention of gastrointestinal variceal bleeding has attracted wide attention and received good results. In this group of elderly cirrhosis patients with high-pressure pulse, sublingual NG 0.5 mg for 30 minutes showed visible mild expansion of Dpv, obvious reduction in Vpv, and significant reduction in Fpv. However, its intensity varies with the disease condition; it is more evident in classes A and B, while not so obvious in class C.
NG sublingual action is sustainable for 30 minutes, but the peak is short. This shows that within 30 minutes, Fpv of NG decreased, MBp decreased, and both were positively related, while HR increased. This is consistent with the literature. NG acts on the vascular smooth muscle wall via special nitrate receptors, causing vascular relaxation. This makes the pulse system and the body supporting blood vessels dilate, reducing resistance and decreasing portal pressure. At the same time, venous distension and venous congestion reduce cardiac preload and afterload, thus reducing cardiac output, which is also one of the reasons for the reduction of portal blood Wei.
It also shows that as arterial pressure decreases, baroreceptor-stimulated sympathetic nerve activity from the reflex bow l-mediated visceral Divertimento blood arm reaction reduces portal venous blood flow and pulse pressure. However, for C-class intensive patients, due to their usually being in a compensatory sympathetic excited state, the application of NG cannot enhance its activity or the NG-induced arterial pressure decrease mediates a weak visceral vasoconstrictor response.
Therefore, less severe cirrhosis of the liver in patients with advanced applications of NG hepatic blood flow, reduce the role of portal pressure in this group of elderly patients have uneven move spicy, coronary heart disease, and performance. We apply NG effectively reduce portal pressure, but also avoid aggravating impaired liver function caused by the role of reduced blood Wei.
NG is an ideal lower f] pulse pressure, vasodilator drug for the prevention and treatment of esophageal and gastric variceal bleeding. Due to its short duration, it is optimal for elderly liver sclerosis patients with upper gastrointestinal bleeding for temporary application.
**Changchun City Hospital**