The nuclear genome of a glacier ice brings new insights.

by dekokfo399 on 2012-03-01 15:44:07

The full genome Ötzi the Iceman has now been published in Nature Communications. The results show: He had brown eyes, blood type "O", was lactose intolerant, and died of heart disease. They also show that he is the first recorded case of infection from Lyme disease bacteria. Analysis of the abnormal Iceman series' DNA also revealed that he is more closely related to modern residents of Corsica and Sardinia than populations in the Alps, where his body was discovered. "These exciting results have enriched our understanding of the genetic map of the Iceman's nuclear cells. The nuclear DNA, generally preserved much less well than mitochondrial DNA, the 'power plants' of the cell which also contain DNA, has provided us with these insights." "This is very exciting, and I think this is just the beginning of a longer level of research. We also want to learn more from this data; we've only just started analyzing it." A reconstruction of the Iceman shows what he may have looked like moments before he was felled by an arrow. Previous sequencing of the Iceman's mitochondrial DNA, completed in 2008, showed some clues about his origins but was not as informative as the newly completed nuclear DNA sequencing. Albert Zink, from the Eurac Institute for Mummies and the Iceman in Bolzano, Italy, said that the nuclear DNA study represented a huge leap forward in the most extensive scientific study of the specimen. "We have been studying the Iceman for 20 years. We know a lot about the places he lived and how he died, but little about the genetic information he carried," he told BBC News. Some new clues have emerged regarding what might be described as the world's oldest murder case: the Iceman, whose 5300-year-old body was found frozen in the Italian Alps in 1991. He carried a "haplotype" that suggests his ancestors most likely came from the Middle East during migrations when farming became more widespread. This could explain the Iceman's lactose intolerance, marking the transition into an agricultural society. Professor Zink said, with regards to next-generation sequencing technology, "it is becoming possible to conduct such analyses." "Whole-genome sequencing allows you to sequence the entire DNA of a sample in a way that wasn't possible before." Related thematic articles: The glacier's nuclear genome brings new insights. Obama mocks Republicans at autoworkers union event. Obama mocks Republicans at autoworkers union event. Not dull, but Dayton is still disappointed. The glacier's nuclear genome brings new insights.