Intravenous infusion of mannitol-induced acute renal injury: a clinical analysis of 25 cases, IANGMEDICALCOLLEGE 2001.11(4). The dosage should be reduced and can be administered via bolus injection if necessary; ④ During the application process, attention should be paid to changes in urine color, urine output, and routine urinalysis, with timely determination of renal function and electrolyte changes; ⑤ If Taiwan disease or infection occurs, one must avoid potentially nephrotoxic drugs that could exacerbate kidney damage; ⑥ When blood osmotic concentration is detected and exceeds 310mOsm/(H, o), water and electrolyte imbalances may occur, and when it exceeds 350mOsrrd(kg·H, O), cell dehydration and renal failure may result. In the event of abnormal renal function, mannitol should be immediately discontinued, and appropriate emergency treatment should be provided, such as an alternative dehydrating agent, mild diuretics like furosemide and dexamethasone, or blood dialysis for severe cases. If dialysis is unavailable, large doses of furosemide (or) diuretic Taiwan agents can be used for treatment, which is better. In short, the use of mannitol should be cautious.