Ankylosing spondylitis is a common disease that affects many young people and causes significant damage to the spine. So, what are the causes of ankylosing spondylitis? Below is a detailed explanation provided by relevant experts.
1. Genetic Factors: The cause of ankylosing spondylitis is closely related to genetic factors. The HLA-B27 positivity rate in ankylosing spondylitis patients is as high as 90% to 96%, and the family genetic positivity rate reaches 23.7%. For rheumatoid arthritis sufferers, the incidence in their families is 2 to 10 times higher than in normal people, while for ankylosing spondylitis, the incidence in families is 30 times higher than in normal people.
2. Infectious Factors: Urinary and reproductive system infections are one of the causes of ankylosing spondylitis. Pelvic infections can spread through lymphatic pathways to the sacroiliac joints and then to the spine. They can also spread to the systemic circulation, causing systemic symptoms and lesions in peripheral joints, tendons, and the eye's uvea.
3. Endocrine Imbalance or Metabolic Disorders also significantly impact people's health: Since rheumatoid arthritis is more common in women and ankylosing spondylitis is more common in men, it is believed that endocrine imbalance is associated with the cause of ankylosing spondylitis. However, hormone therapy for rheumatoid arthritis has not shown significant results, and the relationship between hormonal imbalance and this condition has not been confirmed.
The above is an introduction to the causes of ankylosing spondylitis. Hopefully, you now have a better understanding of ankylosing spondylitis. If you want to learn more about ankylosing spondylitis, please consult the Liang Family Orthopedics Research Institute at http://www.dxtlszg.cn/.
Liang Family Orthopedics, Ankylosing Spondylitis, Avascular Necrosis of the Femoral Head, Fractures