uggs online outlet Optimization of cationic liposome-mediated tissue factor small interfering RNA transfection of HEK-293 transfection conditions L, north face jackets, BartzSR, ScheherJ, eta1. Expressionprofilingrevealsoff-targetgeneregulationbyRNAi [J]. NatBiotechnol, 2003,21 (6) :635-637. XuY. SzokaFC. MechanismofDNAreleasefromcat-ionicliposome/DNAcomplexesusedincelltransfection [J]. Biochemistry, 1996,35 (18) :5616-5623. Hepatocellular carcinoma in the acetylation of heparanase and NM23 expression and clinical significance of Chen Gang Party American Wu Luo temple △ (First Affiliated Hospital of Guangxi Medical University, Ke Nanning 530021) Abstract Objective: To investigate heparanase (HPA) and NM23 in the liver cell carcinoma (HCC) and the expression and clinical significance. Methods: Using immunohistochemistry method was used to detect 72 cases of HCC, ghd outlet, 62 cases of liver cirrhosis and 23 cases of normal liver tissue HPA and NM23 of expression levels, and analyze its relationship with clinical pathological features of HCC.
Results: HPA-positive rate in HCC was significantly higher than the cirrhosis group (P < 0.000) and normal liver group (P = 0.001); in TNM stage I, north face sale, II was significantly lower than the III and IV of (P = 0.001); without lymph node metastasis was significantly lower than the transfer group (P = 0.000); of AFP ≥ 400 # g / L group, UGG Australia España, portal vein tumor thrombus, and multiple tumor nodules group were significantly higher than of AFP < 400g / I group (P < 0.01), nowhere vein tumor thrombus group (P = 0.000) and a single tumor nodule group (P = 0.000). NM23-positive rate in HCC was significantly lower than the cirrhosis group (P = 0.009) and normal liver group (P < 0.000); in the TNM staging of the I and II was significantly higher than III and IV stage (P < 0.001); without lymph node metastasis was significantly higher than the transfer group (P < 0.000); of AFP ≥ # 400 g / L group, and portal vein tumor thrombus group were significantly lower than that of AFP% 400g / L group (P < 0.02) and no one to turn the vein tumor thrombus group (P = 0.005). HPA and NM23 expression was negatively correlated (r = -0.271, P = 0.001).
Conclusion: HPA high expression and low expression play an important role in HCC development and transfer, the joint detection of HPA and NM23 protein targets can help the diagnosis of HCC and determine patients prognosis and NM23.
The Keyword heparanase enzyme; NM23; hepatocellular carcinoma; immunohistochemistry CLC: R735.7 literature flag code: A Article ID: 1005-93ox The (2009) 02-0179 a O4EXPRESSION OF HPA AND NM23 IN HEPATOCELLULAR CARCINOMA AND THEIR CLINICAL SIGNIFICANCE Chen Gang, Dang Yiwu, Luo Dianzhong. (Department of Pathology, the First Affiliated Hospital of Guangxi * Fund: Guangxi subject of scientific research and technological development program (No. Gui Section 05,112,001-4D); Guangxi Natural Science Foundation project (No. Gui Branch 0,542,071) the △ communication of: [email protected] cn, Tel: 0771-5358872 Fax: 0771-5358502 Received date: 2008-05-13 Medical University. Nanning 530021 China)
Abstract Objective: To investigate the expression of heparanase (HPA) and NM23 protein in the tissues of hepatocellular carcinoma (HCC), and their clinical significance. Methods: Immunohistochemistry was employed to detect the expression of HPA and NM23.