Male sterility and correlation between antisperm antibody, relation resultEI, 989, 108: 2163 ~ 268 iceF, laR. et al. Interference of antisperm antibodies with the induction of the acrosome reaction by zona pellucida (ZP) and its reality. An0nshlDjth the inhibition of ZP binding. Fertility Sterility, 1997, 87: 11128 ~ 1113311 Ni Jiang t Geng Jun. Chen Jin. Etc. In seminal plasma antisperm antibody positive patients sperm membrane fluidity changes of China. Journal of Environmental Science, 1999, (3) l4712 Wang Li Hu, Lin Fei. Big dose of prednisone therapy in the treatment of male immune infertility decrements. Chinese Journal of Soil Science, 2000, (3): the 188 Parkinson advances in surgical treatment of Neurosurgery of Beihai People Guangxi (53600) Wang Guang green reviews Wu Quanli trial branch Parkinson disease (Parkinson disease, PD) is a static muscle tremor, muscle rigidity, motor activity starting difficulty, loss of postural reflexes for the characteristics of the central nervous system degenerative diseases. The pathological changes of midbrain dopaminergic neuron degeneration and disappearance led to dopamine in the striatum. Neurotransmitter concentrations decreased, mediated by dopamine neuron excitability decreased. This site acetylcholinergic neurons inhibition attenuates, resulting in the ventrolateral thalamic nucleus (Vim) and pallidal medial part (Gpi) excessive excitement, resulting in PD symptoms.
1PD treatment history and current situation since the beginning of the nineteenth Century that PD O in the early 1990s until twentieth Century. PD is no effective treatment. J0 s. The neurosurgical treatment of PD is the method of brain stereotactic operation, but at the time of the positioning device has the advantages of simple operation, accuracy poor curative effect is not ideal. 7O new medicines for treatment of PD, instead of the surgical operation treatment. Although many drugs can improve the symptoms. But could not prevent disease development, long-term efficacy decline. Side effect increases, there will be on-off phenomenon, end of dose phenomenon and movement disorders. 8O with neuroimaging, electrophysiological and operation equipment advances, stereotactic operation accuracy improved. Thus applying surgical means of treating PD received medical attention, using cell knife for brain nucleus lesioning + fetal brain cell transplantation into the neurosurgeon research direction.
2PD operation treatment mechanism of PD symptoms occur mainly because of the striatum dopamine neurotransmitter concentrations decreased. Brain stereotactic operation is irreversible damage by those for dopamine concentrations decreased after the euphoria of the ventrolateral thalamic nucleus and globus pallidus GPI, make these nuclei reduced excitability. And insufficiency of dopamine neuronal nuclei reaches the level of balance. Thus relieving PD symptoms, but maintained when asked about only 1 to 2 years around 0, if the damage to nuclei and fetal nigral transplants were damaged parts. The transplanted cells once survive, neurotransmitter dopamine concentration can be improved. Maintaining time can reach 4 to 7 years.
3PD operation target selection and location since 1947 Spiegel and Wycis clinical development of stereotactic operation since, a lot of scholars such as Walker, TalairachCooper, canada goose expedition parka, Leksell for the treatment of Parkinson, in the brain to find effective targets. To do a lot of work. From early brain stereotactic operation start to the current of the tremor, rigidity, and other movement disorders of damaged targets with globus pallidus, lenticular ansa, sac, ventral lateral thalamic nucleus and cerebellar dentate nucleus. As far as is known, the cerebral ganglia and within the thalamus these targets. The existence of two different contact fiber. One is the globus pallidus to the ventral lateral nucleus of thalamus group path, probably related with stiff. Another from the cerebellum to the ventral posterolateral thalamic Eucalyptus path, presumably associated with tremor related currently recognized damaged thalamic ventrolateral nucleus treatment efficiency of 80 ~ 90 Parkinson. According to the Anhui neurological function and stereotactic Institute report, destroys the ventrolateral nucleus of the thalamus on stiff front, rear of tremor is best, partial internal on upper limb effectively.