Colorectal mAb Hb3 peanut lectin, carcinoembryonic antigen three marker of chronic ulcerative colon ... ero. 1988; 95(3): 686 Warren I, Fricke H, Einoff CW. Glycopeptide changes and malignant transformation: a possible role for carbohydrate in malignant behavior. Biochem Biophys Acta. The 1978:5](1): 97 Comprehensive Study of Chronic Ulcerative Colitis by McAb Hbs, PNA and CEA Kuang Xiwen, et al (Department of Pathology, Hengyang Medical College. Hengyang, 421001) Monoclonal antibody Hba against human large bowel carcinoma biotin conjugated peanut agglutinin (PNA) and monoclonal antibody against human carcinoembryonic antigen (CEA) were used to study 60 cases of chronic ulcerative colitis, (CuC) and 20 cases of large bowel cancer. The results showed that the positive rates of Hb3, PNA and CEA in large bowel carcinomas were respectively 80%, 85% and 90%. In 70 large bowel carcinomas, all of Hb3, PNA and CEA were positive. In 95 large bowel carcinomas, one of Hb3, PNA and CEA was positive. In chronic ulcerative colitis the positive rates of Hb3, PNA and CEA were respectively 41%, 34% and 53%. In 30 CuC, all of Hb3, PNA and CEA were positive. In 66 CuC, one of Hb3, PNA and CEA was positive. In addition, all of 12 cases of fetal large bowel mucosa showed positive reaction to Hb3, PNA and CEA. Almost all of normal large bowel mucosa showed negative. It is suggested that synthetical detecting of these three tumor markers (Hb3, PNA and CEA) was beneficial to identify that CuC actually has similar biochemical change to large bowel carcinomas and to support that CuC is a pre-cancerous disease of the large bowel cancer. The authors considered that the synthetical detection of these three tumor markers is more practical and accurate than use of one of Hb3, like free run 3.0, PNA and CEA. Keywords: chronic ulcerative colitis; large bowel neoplasm; monoclonal [antibody; lectin CEA · 23 ·