Colorectal cancer and chronic ulcerative colitis immunohistochemical study of malignant transformation: a possible role for carbohydrates in malignant behavior. Biochem Biophys Acta 1978; 516:97 · 349 ·} ’| oath | ■’ ●. H’4tl sin,, I_, suddenly · 350 · c p ’,
Figure 1: Fetal colon revolves around the film with Hb | positive staining located at the membrane of the cavity surface; cavity secretions were positive. (× 400)
Figure 2: Chronic ulcerative colitis with weak inflammation, showing the glass transition cells addicted to replacing Tibetan columnar cells. (× 400)
Figure 3: Chronic ulcerative colitis and Hb | positive staining, with cabinet luminal membrane showing linear distribution. (× 400).
Figure 4: Chronic ulcerative colitis and Hb, positive staining located in the cytoplasm of glandular epithelium (× 400).
Figure 5: Chronic ulcer hemorrhoids colitis. Hb. Positive in the cytoplasm of the glandular epithelium and the luminal surface membrane. (× 200)
Figure 6: Colorectal well-differentiated adenocarcinoma, Hb, positive BU cancerous gland luminal surface distribution, (× 400).
Immunohistochemical Study of Large Bowel Carcinoma and Chronic Ulcerative Colitis by Kuang Xiwen et al. Institute of Oncology, Hengyang Medical College. Monoclonal antibody Hb3 against large bowel carcinoma was used to study 20 large bowel carcinomas, 60 chronic ulcerative colitises (CUC), 12 normal large bowel mucosas, and 12 fetal large bowel mucosas by immunohistochemical method. The results showed that the positive rate of Hb3 binding to large bowel carcinoma · CUC, normal large bowel mucosa, and fetal large bowel mucosa were 80%, 41.7%, 8.3%, and 100% respectively. In addition, the positive rate of Hb3 binding to CUC in the rectal site was higher than those in the colonic site, which agreed with the fact that large bowel carcinomas are easily found in the rectum. Authors considered that the expression of tumor-associated antigen in CUC is a very early biochemical abnormality before morphopathological changes. The present results further support that chronic ulcerative colitis is a precancerous disease of large bowel carcinoma. Therefore, Hb3 immunohistochemical investigation was beneficial for follow-up of CUC and study of the relationship between CUC and large bowel carcinoma.
Keywords: colitis; ulcerative; intestinal neoplasm; monoclonal anti-351 ·