That beloved pair of American good friends returned again. We will find Harold Lee and Kumar Patel again at the place where the last episode ended. When they successfully finished their search for White Castle, they returned to their own apartment. But after almost an hour, Harold and Kumar had already begun preparing luggage for the next adventurous trip. It turned out that Harold's girl Maria went to Amsterdam, and he decided to follow her there and try every means to win her affection. At the airport, Kumar accidentally met his ex-girlfriend Vanessa but was shocked to discover she was about to get married. As a troublemaker, even before boarding the plane, Kumar had a fierce argument with the airport guard and almost missed the flight. But even if the two eventually successfully boarded the plane to Amsterdam, Kumar still managed to create more trouble than expected. Because he couldn't wait for the long hours on the plane, Kumar went to the toilet and made a smokeless device, which caused chaos. The smokeless device was mistakenly recognized as a bomb, and Harold and Kumar were unfortunately regarded as terrorists. This unexpected event caused the plane to change direction and sent them to Guantanamo Bay prison. Although these two unlucky guys always seemed to have bad luck, they had a successful great escape and broke out from Guantanamo Bay. After passing through Miami and arriving in Texas, the location of Vanessa's wedding, the two naturally didn't come just to give blessings. Their purpose was to disrupt the wedding. Following closely behind them was the head of the National Security Agency, Ron Fox, who wanted to recapture these highly dangerous terrorists. Although they experienced many obstacles, Kumar still enjoyed himself as usual and challenged Harold's friendship, patience, and mind once again. But don't worry; no matter what happens, it won't erase their friendship but will make their relationship even closer.