The brothers' journey of catching ghosts and apprehending evil continues; *Supernatural* Season 5 will premiere on [insert date here, as it seems missing in the original text]. At the end of Season 4, we learned that Death is the final seal, but betrayal led to its unauthorized release. Unfortunately, it was too late, as a plan had already been set in motion where an individual kills another, allowing the entity to return from Hell to Earth.
Season 5 will revolve around two main storylines: first, how the protagonists will battle the angels in the apocalyptic showdown; second, whether Sam and Dean, who became estranged in the latter half of Season 4, can reconcile. The regular cast will still include the main characters, with supporting roles continuing as well. It has been confirmed that actor John Noble, known for his roles in *Lost* and *Fringe*, will play a character in Season 5 who was released from Hell at the end of Season 4. Additionally, another actor has signed on to guest-star as a demon transformed into a human in one episode. During the 2010 San Diego Comic-Con, the showrunner revealed that the female hunter and her daughter will also return in Season 5, along with other characters such as the ghost hunters and the prophet making appearances.
(Note: Some parts of the original text are unclear or incomplete, so I made educated guesses based on the context of *Supernatural*. If there's specific information you'd like clarified or adjusted, feel free to provide more details!)