uggs outlet Propranolol, or angiotensin II combined with gastric cancer monoclonal antibody and ... otensinII. JNat / Cance ~ I981i67t663.8HesudaK, eta1. Effieaey of two-route chemotherapy using cis-diaminedichloroplatinum (II) and its antidote, sodium thiosulfate, in combination with angiotensinII for rat liver tumor. StJCcmcx * e1989 £ '4: 373.7GarnettMG, etal · Preparation and property of a drug carrier-antibody directed cytotoxin. Delete I983I3e : 66I . 8 Liangya Yun - gastric cancer monoclonal antibody and MMC crosslinks selective cytotoxic effect on human gastric cancer cells. Pharmacy of 1989I24t897.894 pharmacy of Aeta Pharmaceutica Sinica1992 { 27 ( 12 ) : 891 ~ 894 EXPERIMENTAL STUDY OF TUMOR DIRECTED THERAPY WITH GaSTRIC CANCER MONOCLONAL ANTIBODY-MITOMYCIN CONJUGATE COMBINED WITH PROPRANOLOL OR ANGIOTENSIN II Zhou, NQWang, TLiu and ZWDong ( Cancer Research Institute, Beijing 100034 ) ABSTRACT The effects of vasodilative agents propranolol hydrochloride and angiotensin ( AT-II ) on improving the targeted therapy of cancer using conjugate of gastric cancer monoclonal antibody (3H11) and mitomycin C (MMC) were studied. The antibody activity of the conjugate (3HJ1-HSA-MMC) was retained with the molecular ratio of 1: 2:60. In tests with tumor-bearing nude mice, the tumor inhibitory rate of the conjugate alone was found to be 50%, while in conjugate-treated mice that also received propranolol or AT-II, the tumor inhibitory rates were 79% and 60%, respectively. In tumor-bearing nude mice given [131I] both propranolol and AT-II increased the tumor uptake of 131I labeled 3H11. These results indicate that these vasoactive agents can change the tissue perfusion ratio through their effect on tumor blood vessels and increase the access of the conjugate to the tumor, thereby enhancing the effectiveness of tumor-directed therapy using conjugates. Keywords Monoclonal antibody; Mitomycin C; Conjugate; Propranolol hydrochloride; Angiotensin II