Lectins in Cancer Research
The type of death noted by lectin binding occurs in the positive distribution and swelling blast type. Fisher (1983) reported that PNA receptors in the tubular adenocarcinoma cell membrane are more abundant in the cytoplasm, with more PNA receptors being neutral and revolving around the signet-ring cell protein. However, acidic proteins and signet-ring cells with secretion granules have fewer PNA receptors in their cytoplasm [Ira1 ~ Martin]. The application of lectin binding in gastric carcinoma has been well studied. It was found that in the Bei type gastric cancer, the lectin receptors are mostly distributed along the top surface of the cell. In Frydman crop type gastric cancer, lectin receptors are located in cytoplasmic vesicles, the cell membrane, or the outer layer.
3.6 Tumor Markers and Metastasis: Many experiments have shown that changes in the glycoprotein on the tumor cell surface are associated with tumor metastasis and transfer to specific organs. Foreign authors have reported that subcutaneous primary tumor cell phenotypes for PNA, SBA, UEA-I transfer to the liver blast cell phenotype PNA, SBA, UEAl. Lung metastasis tumor cell phenotypes are PNA, SBA, UEA}. This suggests that cells with SBA and PNA receptors have the potential to transfer, and cells with UEA receptors are transferred to the liver and lungs. Additionally, studies have shown enhanced binding reactions between PNA and highly metastatic medullary carcinomas. The distribution of SBA receptors in high and low metastatic cancers varies. However, some authors have reported similar PNA receptor distributions in primary tumors and metastases. Kellokumpu [] investigated lectins in inverted colon cancer and its metastatic carcinoma. They found that metastatic carcinoma (76)-q differs from primary cancer in its surface glycoprotein complex Pu. This indicates that primary colon cancer consists of blast cells with different phenotypes. Lectin receptors play a role in tumor cell metastasis and primary tumors.
3.7 God Plague Mark: The relationship between American scribe tumor agglutination labeling and its complex longum and survival represents a new field in cancer research. Many data indicate that the complex set of objects on the surface of tumor cells is related to tumor obstruction, transfer, and redevelopment. These biological characteristics are closely related to prognosis. Agglutination cables have specific bindings with specific glycosylation holdings, making it possible to study prognosis. HPA studies [179] reduced the risk of breast cancer recurrence after mastectomy specimens. Tracking patients for 15 to 20 years showed differences in recurrence periods and survival times between HPA-positive and HPA-negative groups. Other experiments also proved that ConA-negative breast cancer has a better prognosis than ConA-positive breast cancer. Domestic scholars have reported that more than 2 years after recurrence of hepatocellular carcinoma in West Africa, single-leaf agglutination cable receptors were significantly less than those within 2 years of recurrence, suggesting that BSA receptor levels in tumor tissue may be an indicator of prognosis after hepatectomy.
3.8 Tumor Dong Lei Su Different Marker: Some swelling swellings of the liver, the diagnosis of malignant fibrous histiocytoma RCA receptors, and fibrosarcoma RCA receptors were examined. The positive rates of WGA and RCA in lung cancer were 79 (22/28) and 93 (26/28), respectively, which are lower in mesothelial plagues, indicating that they are useful markers for differential diagnosis of these tumors.
1.103 Skin Basal Cell Cancer: Studies on PNA binding in skin basal cell cancer and other skin swellings showed that 96% of basal cell carcinomas were PNA receptor-positive, while other skin swellings were negative. Therefore, PNA is a very useful tool for identifying basal cell carcinoma and distinguishing it from other skin swellings.
In summary, the application of agglutination has always focused on changes in tumor cell complexes. It may be possible to explore the development of tumor cells at the molecular biology level, opening up a new avenue for arrest. This may provide a new index for early diagnosis and Kam-cut diagnosis of tumors.