The expression of the Survivin gene in bladder cancer markers determines positive agar gel electrophoresis with molecular size control. 1.4 Statistical analysis of experimental data with a positive rate (%), entering the SAS statistical analysis software package for inspection and analysis. 2 Results 2.1 In transitional cell carcinoma (TCC) of the bladder, bladder transitional cell papilloma, and normal bladder mucosa, Survivin gene expression was studied. The Survivin gene RT-PCR product of 338 bp was referenced to GAPDH at 456 bp. 76.27% (45/59) of bladder TCC expressed the Survivin gene, while the expression in bladder transitional cell papilloma and normal bladder mucosa was 16.67% (2/12) and 0 (0/16), respectively (χ² = 37.29, P 0.05). This suggests that gene expression and biological behavior of bladder tumors are not closely related.
In summary, the Survivin gene is highly expressed in bladder cancer cells. Survivin may inhibit bladder tumor cell apoptosis and have a synergistic effect with other apoptosis genes, playing an important role in the occurrence and development of bladder tumors. Therefore, the expression of Survivin can be used as a basis for the early diagnosis of bladder cancer and as an important positioning point for subsequent targeted therapy of bladder tumors, guiding the treatment of bladder tumors accordingly.