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Previously reported studies suggested a connection between milk intake and renal cell carcinoma risk, and whether this represents a causal association or is the result of bias is currently unclear. Timpson and colleagues used a genetic marker to try to help untangle this observation. From 1999 through 2003, the researchers conducted a large, hospital-based case-control study from four central and eastern European countries. Using observational, genetic, and phenotypic data, they determined whether the genetic variant at the gene MCM6 — known to be associated with lactose tolerance — may be used as a non-confounded and unbiased marker for milk consumption's link to cancer risk. For adult milk drinkers vs. non-milk drinkers in this study, the difference in the odds of renal cell carcinoma was approximately 35 percent. However, when assessing the relationship in a more direct way by using genetic data, there was no association between the two.
"We found evidence for the often-questioned relationship between milk consumption and cancer, yet when we used genotypes to verify this relationship, there was no corroboratory evidence," Timpson said. "This does suggest that the basic findings may be subject to the kinds of biases and inaccuracies that often upset epidemiological research, but that this study would need to be undertaken on a much larger scale in order to verify these initial findings."
Johanna Lampe, Ph.D., an editorial board member of Cancer Epidemiology, Biomarkers & Prevention who is not associated with this study, said this study demonstrates the complexities of evaluating dietary exposures and cancer risk. "These results are a reminder to proceed with caution when interpreting data that suggest an association between intake of specific foods and risk of a particular cancer. Human diet is complex and typically involves adherence to certain dietary patterns that are also tied to other lifestyle behaviors," said Lampe, full member and nutrition scientist in the division of public health sciences at Fred Hutchinson Cancer Research Center, Seattle, Wash.
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Kintaro is characterized by a tiger-striped Shokan who joins Kahn’s forces in the hope of avenging Goro’s death. Kintaro first appeared in MKII as the sub-boss where he competes with Liu Kang during the second tournament but lost. In MK: Armageddon’s Konquest mode, Kintaro can be seen in the Netherealm together with Sheeva, Havik, and a legion of demons attempting to overthrow Shinnok’s rule. This action is considered just a test for Taven with Kintaro merely an illusion. He was seen transforming into Kintaro before swiping his opponent in half.
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