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After escaping from the hellish Sona prison in Panama, brothers Michael Scofield and Lincoln Burrows decide to mete out justice and take down the Company, the shadowy organization that has ruined their lives and murdered Michael's beloved Dr. Sara Tancredi. On their path of vengeance, when Michael discovers that Sara is still alive, the brothers realize that the only way for them to reclaim their lives and achieve true freedom is to find Sara and completely destroy the Company.