Common quality problems of Chinese medicine granules. In addition, the wet grain after the swinging particle mechanism with boiling dry or vibration far infrared drying, the resulting particle appearance and color are bright, uniform, and production efficiency is high. 4 Particle size does not meet the provisions: 1) Granulation step, such as atomization pressure being too large, inlet air temperature being too high, making the spray droplets of material powder bond into contact with the end of the grain prior to drying, resulting in too much powder; conversely, making the spray droplets not dried in time leaving the material agglomeration, resulting in too many large particles or clumps. The solution is to choose the appropriate operating parameters for different varieties. 2) At Fang Zhongqing paste, less viscous accessories make the system of particles insufficient. On the contrary, it leads to more large particles or clumps. The solution: the former can use the binder granulation, which try to switch to step granulation, this method can clear grease particles in the proportion of 50% to 70%, is particularly suitable for the clear grease more accessories less Chinese medicine sucrose particle production. 3) In the use of wet granulation, the wet granules have not been dried in time, or during the drying process, the particle flow is in a bad state, absence of timely flip, leading to particle agglomeration, drying of large particles or clumps more. The solution: drying the wet granules in a timely manner, and keep the particles in a fluidized state. Such as the use of hot air circulation oven drying, should be regularly flipped, and control the temperature. 4) The whole screen specifications improper selection or screen damage. Solution: appropriately narrow the selection screen specifications, the choice of the second sieve (24 mesh) and the fourth screen (65 mesh) whole. 5) The whole feed rate too fast, time excessive, so that the particles have not been fully screened by oscillating discharge in the sieve. The solution: uniformly appropriate amount of feed. 5 Water does not meet the requirements, excessive moisture generally occurs in the granule storage, the process of circulation. 1) Within the material of the packaging material does not meet the requirements. The solution: switch to aluminum foil composite film packing particles. The composite membrane made of different materials has a great influence on the stability of the drugs, aluminum foil composite film is significantly better than the aluminized plastic film, aluminum plastic composite film is better than the plastic film 1.2) package pouch sealing lax , leading to pouch leak moisture. Solution: Adjust the horizontal sealing granule packing machine roller and the heating temperature of the longitudinal sealing roller-packing process in a timely manner with copper wire brush to remove attached particles on the pressure roller pouch incision can be fused seal securely. 6 Determination of failure 1) The original ingredients ingredients do not meet the requirements. Solution: strengthen the quality inspection of raw herbs, does not require the determination of the herbs in the pharmacopoeia, reference preparation standard related to internal control content 2) The extraction and preparation process standards are unreasonable, active ingredients from incomplete or destroyed loss. Solution: strictly adhere to the process standards. Prolonged exposure to wet heat perishable product, can be used for materials without pressure wet and thermal process dry granulation. 7 Conclusion Chinese medicine granules to produce the actual causes of quality problems, there are many in this list. With the rapid development of modern pharmaceutical technology, new accessories, new materials, new equipment, the continuous application of new technology, the continuous improvement of quality standards, the production process of traditional Chinese medicine granules may have other quality problems, therefore, the related production units should be highly valued. Author: Wang Fang, l (1965), in charge of pharmacists practicing pharmacists engaged in drug development and production technology research, (e-mail) wzr6618 @. Tom. corn.