Anti-tumor benzo two pyrrole antibiotics - monoclonal antibody conjugates ucturalelucidationofnovelanaloguesoftheantibioticCC a 1065 Review and monograph 2008 G32 g4 157 andtheduocarmycins [J]. Chemistry, 2007,ghd outlet,13 (16): 4396.4O9. Pharmacological postconditioning protective effect in myocardial ischemia and reperfusion injury Zhang Lina, Wu Yulin ’(China Pharmaceutical University, School of Pharmacy, Department of Physiology, Nanjing 210009) [Abstract] Summary of the drug adaptation of the background and progress. Drugs after the adaptation is to adapt the method through simulation of myocardial ischemia after myocardial ischemia adaptation mechanism, research the role of drugs to stimulate or presented by the analog of endogenous protective substances protect the heart, is one of the new way to protect the heart. [Key words] drug adaptation； ischemia and reperfusion injury； myocardial infarction [CLC] R972-A Article ID 1001-5094 (2008) 04-0157-06 Protective Effect of Pharmacologic POst COnditiOnng on Myocardial Ischemia-reperfusion Injury ZHANG Li-na. WU Yu-lin (Department of Physiology, China Pharmaceutical University, Nanjing 210009, China) [Abstract] Pharmacologic postconditioning is based on the mechanism of ischemic postconditioning by the methods of simulating postconditioning to study the cardioprotective role of drug-inspired or simulated endogenous protective substances. Pharmacologic postconditioning is one of the new ways to protect the heart. In this article, the status and progress in this field were reviewed. [Keywords] Pharmacologic postconditioning, north face jackets,； Ischemia-reperfusion injury； Myocardial infarction drug adaptation is developed on the basis of myocardial ischemic preconditioning, by drugs to stimulate or simulate the body’s own endogenous protective substances presented to protect the heart role. It has been to adapt a cardiac drug’s Preconditioning one myocardial ischemia to adapt to a cardiac drug development process from myocardial ischemic preconditioning. Drugs to adapt to drug substitution ischemic stimulus to overcome the drawbacks of ischemic injury, myocardial protection and create a broad prospect. In 1986, Murry, ligation of dogs after coronary artery, can significantly reduce the subsequent longer time of ischemia caused by the depletion of high-energy phosphate compounds and myocardial infarction.. 1990, Deutsch ... reported in patients with coronary heart disease, myocardial ischemic preconditioning phenomenon and found that the degree of anterior descending coronary artery occlusion caused by angina, miu miu borse, the degree of ST-segment deviation and myocardial lactate levels were lower than that time. Since then a large number of findings are confirmed myocardial ischemic preconditioning has a protective effect on the heart. At present its Corresponding author: Wu Yulin, Ph.D., north face uk, associate professor； Research Interests: Cardiovascular Pharmacology； Tel :025-85,230,873； E-mail: wylcpu @ yahoo. com,. ca