moncler pas cher COX - 2 expression in primary gallbladder carcinoma and its correlation 29) was significantly higher than the expression of COX -2 negative cases ( 2O ,north face jackets, 2/10 ) ( P <0.05) . The positive expression rate of COX-2 and histological grading, tumor size, patient gender , age has nothing to do with the prognosis of patients . This suggests that COX- 2 expression was significantly positively correlated with the malignant biological behavior of primary gallbladder . Gallbladder cancer is highly malignant tumors , there is no effective control methods , only a very small number of patients after radical resection can survive more than six months . The study confirmed c0x a 2 was over- expressed in colon carcinoma , was significantly negatively correlated long-term use of COX-2 inhibitors and incidence of colon cancer , colon cancer can occur relative risk reduction 4O ~ 6Old , and the use of high selectivity sexual COX -2 inhibitors to successful prevention and treatment of colon cancer development l5 ] . Wugao Song , etc. _6 studies have found that COX -2 Selective Inhibitor Celecoxib rate of reduction in gallbladder carcinoma GBC-SD cells of COX -2 protein expression , significantly inhibited the GBC-SD proliferation and induction of apoptosis , and this effect was time and dose dependence. The study also found that Celecoxib, may be a significant release of PGE2 inhibition of gallbladder carcinoma GBC-SD cells , and Celecoxib inhibited the growth of gallbladder carcinoma cells GBC-SD and induction of apoptosis can be PGE2 antagonized by inhibition of GBC-SD cells proliferation and induction of withered Deｓｃｒｉｐｔion Celecoxib death role is by PGE2 way to achieve . The experiments showed that Celecoxib can cause GBC-SD cell cycle distribution showed a G0/G1 arrest . Prompt Celecoxib as a chemical treatment and chemoprevention drugs may be effective for COX- 2 expression in gallbladder cancer . This gives us inspiration, you can use the highly selective COX -2 inhibitors in high-risk groups of primary gallbladder ( gallstone , gallbladder adenomatous polyps , gallbladder adeno- muscle hyperplasia , xanthogranulomatous cholecystitis , porcelain gallbladder patients) prevention and control work , the use of effective prevention and treatment of COX-2 inhibitors after recurrence and metastasis .