Laurence-Moon-Biedl syndrome associated with chronic kidney disease patients: Laboratory tests: blood: WBC: 6.0X109 / L, N: 54.7%, HGB: 108g / L, PLT: 328 × 109 / L; urine: occult blood (4 -), white blood cells (+) The urinary sediment: WBC 10 / L; blood biochemistry: serum phosphorus 1.80mmol / L, and carbon dioxide 16.6mmol / L, urea nitrogen 17.3mmol / L, and creatinine 431mol / L, and uric acid 321mol / L, triglycerides 3. 06mmol / L, total cholesterol of 3.78mmol / L, high density lipoprotein 0.86mmol / L, and LDL 1.53mmol / L, albumin 38. Og / L, globulin 42g, I, alkaline phosphatase 445U / L; hepatitis B surface antigen negative. The final diagnosis: the fixation of the Laurence-Moon-Biedl syndrome, chronic kidney disease stage Ⅳ, bilateral ureteropelvic junction obstruction after surgery, the right cryptorchid testis. 2 to discuss 1866 first reported by Laurence and Moon, Bardet and Biedl syndrome clinical features has been further elaborated, it was named labor a Mu than three’s syndrome. The disease is rare, of unknown etiology, is generally believed that the autosomal recessive genetic disease, often a positive family history increased incidence of the children of consanguineous marriage, the vast majority of children with chromosome examination was normal, autopsy hypothalamic or pituitary birth defects, causing a lack of gonadotropin secretion, the disease than childhood-onset. More men than women, 140 Chinese doctors CHINAMODERNDOCTOR about 2: l. The typical clinical manifestations: ① obesity; ② The mental retardation; ③ multi-finger and pointed, or both are; ④ retinitis pigmentosa; ⑤ The genital hypoplasia, sexual dysfunction, or both. Associated with other malformations, kidney damage, hypertension, heart defects, urinary tract abnormalities, nystagmus, strabismus, diabetes, hirsutism, ovarian stromal hyperplasia, short length [21. Clinical features can be divided into five types [31: ① complete type: five have the whole, obesity, mental retardation, vision loss, and five performance multi-finger (toe) deformity and genitalia dysplasia; ② incomplete type: lack of one to two persons, such as no dysplasia (toe) deformity or external genitalia; ③ frustrated type: 1 to 2 performance, others are less clear; ④ The atypical type: retinitis pigmentosa, but accompanied by optic atrophy, outer eye muscle paralysis, high myopia, small eye and other eye diseases; ⑤ The expansion of the progressive: In addition to the six cardinal symptoms associated with other congenital malformations. There is renal dysfunction belong to expand the progressive in this case, the appeal five performance. Should be noted that the diagnosis of the syndrome (obesity, retinal degeneration, nerve deafness and renal disease), Froehfich syndrome (obesity, sexual organs dysplasia, mostly caused by a brain tumor), Klinefetter syndrome (men with As ~ om primary gonadal dysfunction, the performance of sexual developmental disorders, obesity, taller), Prader-willi syndrome (muscle weakness, mental retardation, sexual dysfunction, obesity), Cushing’s syndrome be differentiated [4 | 51 . No specific treatment for this disease, the use of symptomatic treatment. The main causes of death have kidney disease and cardiovascular disease. [ ],[