Determination of Benzyloxy Benzyl Chloride by HPLC
No feeding determination method other than the standard method was used to measure the batches 20040301, 20040302, and 20040401. The content of the samples were 97.2%, 99.0%, and 98.6% respectively.
3. Discussion: The substance decomposes easily in water, so an aqueous solvent was used as the mobile phase. Preliminary tests involved using different proportions of methanol, water, and acetonitrile. Water, acetonitrile, tetrahydrofuran, and methanol were all tested as mobile phases. Results showed that using methanol as both the solvent and the mobile phase provided sample stability and better separation.
China’s Pharmaceutical Industry Magazine, Chinese Journal of Pharmaceuticals, 2005, Volume 36 (Issue 10).
Summary and Monographs: Research Progress of Sialic Acid Class Neuraminidase Inhibitors
Zhang Jie, Xu Feet Square (Shandong University School of Medicine, Jinan, Shandong 250012, China)
Abstract: A review of the structural progress of sialic acid class neuraminidase inhibitors in anti-influenza virus drugs is presented.
Keywords: neuraminidase; sialic acid; inhibitor; design; synthesis; review
CLC Number: R978.7 Document Code: A Article ID: 100l-8255 (2005) 10-0643-05
Influenza is an acute viral respiratory disease caused by the influenza virus, highly infectious, with a wide range of prevalence and high incidence, posing a serious threat to human health. One of the reasons for the influenza virus epidemic is its antigenic variability, which prevents permanent immunity in the human body. Before the discovery of neuraminidase (also known as sialidase, NA) inhibitors, influenza treatment was limited to amantadine/rimentadine and viral vaccines. Colman et al. [1] in the early 1980s identified the active site of influenza virus NA and its role in breaking the glycosidic bond of sialic acid. This has a significant role in the release of new virus particles from infected host cells. Suppression of NA can interfere with and prevent virus replication, achieving the purpose of treating influenza. Using sialic acid (sialic acid, SA) as the parent compound for NA inhibitors has become a hot spot in anti-influenza drug research, resulting in two effective treatments: zanamivir (zanamivir, 1) and oseltamivir (oseltamivir, 2) being listed [3].
Received: September 20, 2004
Description: Zhang Jie (1981), male, graduate, professional direction: rational drug design.
Tel: 0531.88382264 E-mail: [email protected]
NHH N-sound Nll1 Influenza Virus and NA Special
1.1 Influenza Virus
The influenza virus belongs to the orthomyxoviridae family, consisting of spherical or filamentous single-stranded fragments of negative-sense RNA viruses.
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