The nuclear genome of the glacier brings new insights.

by ddenglk168 on 2012-03-01 15:52:58

"We've been studying the Iceman for 20 years. We know so much about Jesus Christ, where he lived, how he died, but very little about his genetic make-up," he told BBC News. New clues have also emerged in what could be described as the world's oldest murder case: the glacier "Iceman", whose 5,300-year-old body was discovered frozen in the Italian Alps in 1991. It shows a reconstruction of what the glacier man perhaps looked like before the arrow felled him. The mitochondrial DNA of the glacier man has yielded some tips on his origins when it was fully sequenced in 2008. Albert Zink, from Eurac's Institute for Mummies and the Iceman in Bolzano, Italy, says nuclear DNA study is a huge leap forward in the widest scientific examination of the specimen. The entire genome of Oetzi the glacier man has now been published in Nature Communications. The results show that he had brown eyes, blood type "O", lactose intolerant, and prone to cardiovascular disease,. They also show that he is the first recorded case of infection by a bacteria that causes Lyme disease. Analysis of unusual series of the Iceman's DNA also revealed that he is more closely related to modern residents of Corsica and Sardinia than populations in the Alps, where he was uncovered. "These exciting results really fill out the genetic picture of the cell nucleus of the glacier man. The nuclear DNA, which is generally rare and not as well preserved as the DNA within the mitochondria - the "power plants" of the cell, which also contain DNA. "This is very exciting, I think this is just the beginning of a longer phase of research. We want to learn more from this data, we're just starting to analyse it." He carried a "haplotype" that indicates his ancestors most probably came from the Middle East as part of a migration that coincided with the spread of agriculture. This might explain why the Iceman was lactose intolerant. Prof Zink says next generation "becomes" sequencing technology made the analysis possible. "Whole genome sequencing allows you to sequence an entire DNA sample in the way that was impossible before." Related subject articles: Website net promotion company professional search engine optimization The nuclear genome of the glacier brings new insight Not boring, but still Dayton very disappointed Not boring, but still Dayton very disappointed The nuclear genome of the glacier brings new insight