Involved in the treatment of secundum atrial septal defect analysis of 18 cases ASD commonly used devices. Septal defect secondary larvae L-shaped room is divided into central, on the cavity type, cavity type and mixed type, central type is the most common clinical indications of the Amp / atzer occluder diameter (balloon stretching the measured value) 5mm. Echocardiography plays a key role in larvae L ASD Amplatzer occluder secondary, while blocking the success and efficacy of the choice of device size is directly related to blocking. AmplatzerASD occluder and occluder in its use of the waist and its filling is not closed of ASD is generally ASD stretch diameter or larger than 1 ~ 2mm selected occluder. Of Statistics, slightly less than the stretched diameter, equal to the stretched diameter than the large 1 ~ 2mm or greater than the stretched diameter of 2mm or more different occluder plug ASD immediately and 24h plugging rate, the results show that ASD stretch diameter or more than large 1 ~ 2mm choose to block the effect of the best the J. Amplatzer occluder device complications include the occluder loss, embolism, need emergency surgery. Intraoperative air embolism, postoperative thrombosis leading to embolization of cerebral infarction, or other organs, endocarditis, arrhythmia, and the re-closure of residual shunt need surgical ASD complications than rare. 20 cases in this group, aspirin anticoagulation, intraoperative heparinization and heparin saline flush full sheath, after 3 days of intravenous anticoagulation in preventing infection, this group had no serious complications. Amplatzer occluder and domestic self-expanding room 18 patients were missing occluder interventional treatment, the surgical success rate of up to 100% were no coil displacement, no residual shunt occurred, no other serious complications were reported in the literature. This study shows that: the two occluder is right in line with the indications and secondary larvae L in patients with ASD transcatheter occlusion have shorter operative time, low complication rate, trauma, quicker recovery, etc., and successful block, right atrial, right ventricular load can be significantly reduced, efficacy and surgery. The occluder to avoid the complications of thoracotomy, reducing the patient’s mental stress, greater indirect benefits, is a very promising ASD non-surgical methods, and because of the septal occluder and Amp. Design principles 1atzer intervention therapy in we found that both undifferentiated and long-term efficacy requires further observation, but lower than the Amplatzer septal occluder price, so the family income is a good choice . [ ,],[