Hematopoietic stem cell transplantation involves isolating hematopoietic stem and progenitor cells (CD cells) from the bone marrow or umbilical cord blood with high purity, using the ClinicMACS system. The purity of isolated CD34+ hematopoietic stem cells from mobilized peripheral blood is higher than 95%. This process can also eliminate tumor cells in the sample by about 3 to 4 log levels and 4.5 pairs of log T lymphocytes. More than 3,000 cases of CD cell sorting have been completed worldwide using this sorter for cell purification. It is used in both autologous and allogeneic stem cell transplantation.
According to available information and development trends, CD cell purification and sub-selected transplantation is an ideal treatment option, especially for individuals without a suitable donor or those who are single children. In recent years, the popularity of hematopoietic stem cell transplantation has grown, and some developed countries around the world have initiated programs to register unrelated donors for non-blood-related matching (matched unrelated donor MVD). To date, there are over 180 million unrelated bone marrow donors registered worldwide.
Another type of transplant gaining attention is non-myeloablative allogeneic hematopoietic stem cell transplantation (NAST), which builds on conventional allogeneic hematopoietic stem cell transplantation (allo-BCT). NAST represents a new field in transplantation, significantly reducing pre-treatment intensity while enhancing immune processing before transplantation. It has relatively mild complications, offers quality-of-life advantages for patients, and is thus receiving considerable domestic attention. Besides updating classic allo-SCT theories and concepts, NAST also plays an important role in defining organ transplantation and treating immune deficiency diseases or genetic deficiencies.
With increasingly in-depth research into hematopoietic stem cell transplantation, it is believed that in the future, this approach will be able to cure more deadly diseases.