Overview of Placenta Extract Recommended for Treating Erectile Dysfunction
Overview of drugs for treating erectile dysfunction. There are many contemporary methods for treating erectile dysfunction, but the most favored are the simple-to-use oral medications. The following fashionable and widely used oral drugs for treating erectile dysfunction include:
1. Viagra: The oral drug Viagra, officially introduced in 1998 for treating erectile dysfunction, is commonly known as "Viagra." Due to its good and unique effects, it has drawn worldwide attention since its release. The mechanism of action for Viagra is based on the theory that nitric oxide promotes penile erection. Specifically, under sexual stimulation, a large amount of nitric oxide is released from nerve endings and enters the smooth muscle cells of the penile corpus cavernosum, increasing the levels of cyclic guanosine monophosphate (cGMP) within the cells. cGMP relaxes the smooth muscles of the penile corpus cavernosum, leading to increased blood flow and erection. Therefore, the quality of penile erection depends on the quantity of cGMP. Higher levels result in erection, while lower levels do not. However, in the penile corpus cavernosum tissue, there is another substance called phosphodiesterase-5 (PDE-5), which breaks down cGMP, reducing its quantity and negatively affecting penile erection. Viagra inhibits PDE-5, ensuring sufficient levels of cGMP in the penile corpus cavernosum, thereby ensuring penile erection. According to clinical trials involving 628 cases in our country, taking 25-100 mg of Viagra one hour before sexual activity resulted in an effective improvement rate of erectile function in patients with erectile dysfunction reaching up to 81%. Our hospital treated 91 out of these 628 cases, achieving an even higher improvement rate of 88%. The side effects of the medication were not significant, mainly including facial flushing, nasal congestion, and visual abnormalities, all of which were mild and transient, generally not affecting continued use. Using Viagra concurrently with nitrate medications can lead to additive drug effects, causing a sudden drop in blood pressure, posing a certain level of danger; therefore, it is absolutely contraindicated for those using nitrate medications for coronary heart disease. Additionally, caution should be exercised when suffering from active heart disease, severe hypertension, bleeding disorders, or retinitis pigmentosa. The common dosage of Viagra is 25-100 mg, with most patients using 50 mg, taken orally one hour before intercourse, requiring sexual stimulation to take effect.
2. Phentolamine: This is also an adrenergic receptor blocker. Similar to yohimbine, it can block adrenaline activity in the penis, specifically targeting 90% of alpha-1 type adrenergic receptors, making its treatment effectiveness surpass yohimbine, reaching 50%-60%. The usual oral dose is 40 mg taken once before each sexual activity, with some individuals taking up to 80 mg. Possible side effects include mild headache, dizziness, and vertigo.
3. Trazodone: This is an antidepressant whose mechanism for treating erectile dysfunction involves a substance called serotonin. Overall, serotonin is universally considered to inhibit sexual physiological activities, undoubtedly being detrimental to penile erection. Trazodone, also known as chlorotriazodone, although classified as an antidepressant, has been found to inhibit serotonin, thus promoting penile erection, leading to its repurposing for treating erectile dysfunction. Clinical observations at the hospital showed an effectiveness rate of around 50%; literature reports indicate a 65% effectiveness rate for psychogenic erectile dysfunction. The common dosage is 50 mg per time, three times daily, taken orally, sometimes resulting in drowsiness as a side effect.
4. Sex hormone drugs: Androgen deficiency can lead to erectile dysfunction, and supplementing androgens can treat it. Even if androgens are not deficient, short-term use of small amounts of androgens can help overcome erectile dysfunction. Currently, the representative and highly effective androgen drug for treating erectile dysfunction is oral undecanoate testosterone (brand name Andriol), taken at 80-160 mg daily, divided into morning and evening doses, with an effectiveness rate for improving erectile function exceeding 80%, and very few side effects. Patients with benign prostatic hyperplasia or prostate cancer should avoid its use.
5. Apomorphine: This is a highly effective dopamine agonist. Dopamine in the human body promotes sexual function. Animal experiments have confirmed that using dopamine agonists can significantly promote penile erection. Conversely, destroying dopamine in animals significantly reduces sexual function. Apomorphine activates dopamine function in the human body, promoting penile erection. The common dosage is 2 mg sublingual administration. According to relevant data, about 1 hour after use, 45%-60% of patients with erectile dysfunction can successfully engage in sexual intercourse. Side effects may include nausea, vomiting, dizziness, drowsiness, and sweating.
6. Yohimbine: This is an alpha-adrenergic receptor blocker. Penile erection relies on the relaxation of the smooth muscle tissue of the penile corpus cavernosum, allowing large amounts of blood to enter, making the penis firm. However, a substance called alpha-adrenaline causes the smooth muscles of the penile corpus cavernosum to contract, promoting penile flaccidity, which is detrimental to penile erection. If a drug could block this adrenaline activity, wouldn't it be useful for treating erectile dysfunction? Alpha-adrenergic blockers belong to this category of drugs. In human penile tissue, alpha-adrenergic receptors can be divided into alpha-1 and alpha-2 receptors, with alpha-1 accounting for 90% and alpha-2 for 10%. Yohimbine mainly blocks alpha-2 receptors, aiming to promote penile erection. However, due to the smaller proportion of alpha-2 receptors, the effectiveness of yohimbine in promoting penile erection is not ideal, with an overall improvement rate of 46% for psychogenic erectile dysfunction, where only half can engage in sexual intercourse; the effect is even worse for erectile dysfunction caused by diseases. The oral dose is 5.4 mg per time, three times daily, requiring continuous use for over 3 weeks to begin taking effect, with no adverse reactions.
Placenta extract, human placenta, human placental extract, human placental tissue fluid (placenta, Zi He Che) has a very long history in China. Historical records show that as early as the Qin Dynasty during the reign of Emperor Qin Shi Huang, placenta was used as a royal health necessity. Emperor Qin Shi Huang's use of placenta aligns with his pursuit of immortality. The use of human placenta among the common people mainly revolves around "tonifying deficiency, infertility, and enhancing male sexual function."
So how does placenta extract, human placenta, human placental extract, human placental tissue fluid (Zi He Che) enhance sexual function? According to classical Chinese medical texts such as "Compendium of Materia Medica," "Supplement to the Compendium of Materia Medica," and "Modern Chinese Medicine Dictionary," Zi He Che (human placenta) has the functions of "greatly tonifying primordial qi, supporting the body's normal state, tonifying the kidneys and strengthening yang, nourishing blood and replenishing essence, calming the spirit and stabilizing the mind, invigorating qi and strengthening the spleen."
Modern pharmacological studies have found that placenta extract, human placenta, human placental extract, and human placental tissue fluid (Zi He Che) are rich in various amino acids and abundant proteins such as albumin, globulin, macroglobulin, and multiple placental globulin antibodies. They contain multiple active substances essential for human physiology and more than 55 types of enzymes necessary for human physiology, such as hyaluronidase and protein synthesis enzymes, which play a crucial role in maintaining normal human endocrine function. Their significance lies in ensuring the body remains healthy, maintaining various bodily functions in a vigorous state, effectively improving organ dysfunction, delaying physiological decline, and ensuring and extending the youthful state of the body. Based on the results of pharmacological research, placenta extract, human placenta, human placental extract, and human placental tissue fluid (Zi He Che) are highly effective in treating sexual dysfunction and low sexual function, explaining the widespread clinical use of placenta extract, human placenta, human placental extract, and human placental tissue fluid (Zi He Che) in effectively treating impotence, premature ejaculation, sexual dysfunction, and male infertility.
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