Angels, tremble! The Revenge of Diablo III

A decade has passed in the blink of an eye. Since the defeat of the Three Demon Gods, peace did not arrive. The remaining forces of Hell were leaderless, and the two Demon Kings Azmodan and Belial (the two of the Four Lesser Demon Gods who didn't appear) were killing each other and fighting incessantly. The lower-level demons, being less reliant on the power of Hell, came to Earth to wreak havoc. However, the Heavenly Hosts turned a blind eye to this, claiming that it was the result of humanity's own downfall.

The only ones who could save humanity were humans themselves. A new generation of heroes has grown up and set off on a new journey once again.