FancyUpload is a multi-file, no-refresh upload tool implemented with Flash and Mootools.
Its most prominent feature is the ability to select multiple files at once for upload without refreshing the page.
Some time ago, I considered the issue of selecting multiple files at once. By default, the file input tag in browsers only allows selecting one file at a time. To browse and read local files, it's necessary to invoke local components or commands; therefore, there’s no solution using just JavaScript and HTML.
Today, while checking my subscribed feeds, I unintentionally came across this demonstration on Ajaxian where multiple files were selected in the image shown.