The following is a translation of the provided text into English:
Ralph Lauren shirts. Xuezhikang treatment for hyperlipidemia in 60 patients, analysis of 295 cases of dermatitis. Wang Kun. Dermatitis, also known as drug rash, is a common adverse drug reaction. To investigate the manifestations of drug-induced dermatitis and systemic damage, as well as the trends in drug sensitization, we analyzed 295 patients who received outpatient and inpatient treatment at our hospital between 1998 and 2005. The results are as follows.
Clinical Data:
1.1 General Information: Among the 295 patients, there were 174 males and 121 females, aged between 17 and 82 years, with an average age of 37.8 years. Of these, 49 cases had a history of drug allergy, accounting for 16.6%.
1.2 Rash Types: Fixed drug eruption in 49 cases (16.6%), scarlet fever or measles-like rash in 75 cases (25.4%), eczema or dermatitis in 92 cases (31.2%), bullous skin release and necrosis in 2 cases (0.68%), erythema multiforme in 36 cases (12.2%), urticaria in 28 cases (9.5%), purpura in 12 cases (4.1%), lichen planus in one case (0.34%).
1.3 Systemic Symptoms and System Damage: Among the 295 patients, fever was present in 84 cases (28.3%), suffocation and shortness of breath in 39 cases (13.2%), arthralgia in 37 cases (12.5%), renal damage in seven cases (2.4%). Liver damage (abnormal AST, ALT) in nine cases (3.1%). Abnormal ECG: sinus tachycardia in 26 cases (8.8%), ST segment changes in six cases (2%). It is noteworthy that the more severe types of drug-induced dermatitis often present with systemic symptoms (erythema multiforme, epidermolysis bullosa necrosis, and purpura type).
1.4 Allergenic Drugs: Antibiotics accounted for 181 cases (61.4%), antipyretic analgesics in 42 cases (14.2%), sedative and hypnotic drugs in 31 cases (10.5%), biological agents in 22 cases (7.4%), traditional Chinese medicines in 19 cases (6.4%).
Unit Results: Beijing Millennium Monument Hospital Pharmacy, Beijing 100038, China.
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