Abercrombie and Fitch COX -2 and VEGF expression in bladder transitional cell carcinoma and analysis TPO content and the degree of liver cell damage. The authors suggest that patients with chronic liver disease lead to the aggravation of liver fibrosis and a reduction in the function of liver parenchymal cells, which decreases the liver's ability to synthesize proteins, including reduced TPO synthesis. This leads to decreased stimulation of megakaryocyte progenitor cell proliferation and differentiation, reduced megakaryocyte maturation activity, and a decrease in peripheral platelet count. This proves that TPO plays an important role in maintaining normal platelet levels. The results of this study show that: viral hepatitis, thrombocytopenia, and splenomegaly are related to serum TPO levels. Peripheral thrombocytopenia caused by chronic viral hepatitis may involve dual mechanisms: First, severe impairment of liver function reduces TPO production, leading to thrombocytopenia due to generation obstacles; second, increased destruction of platelets occurs in the spleen.