Nimodipine is effective for right fluoroacetamide poisoning in children with calcium aspartate receptor Ca channel over-activation, which results in a large number of Ca flows, an increase in intracellular calcium, and the decline of Ca bulk flow leading to N-necrosis. Sustained convulsions are one of the factors. Benny lay horizon belongs to the dihydropyridine class of calcium channel blockers. It combines with specific receptors on blood vessels to prevent calcium ions from entering the cell, effectively regulating the levels of intracellular and extracellular calcium, detoxifying, and maintaining normal physiological functions of blood vessels. It has especially selective roles in cerebrovascular brain tissue, being potent and easily passing through the blood-brain barrier. It selectively acts on brain blood vessels and brain tissue, inhibiting cerebral vasospasm, increasing the perfusion of brain tissue, shortening the duration of ischemia in brain tissue, reducing the extent of brain tissue damage, and decreasing the possibility and extent of neurological sequelae.
It's not difficult to see that nimodipine can effectively address calcium changes in children poisoned by fluoroacetamide. In the treatment group, serum calcium was significantly higher, showing significant differences between the two groups. Nimodipine effectively prevents calcium flow caused by hypocalcemia. Hypocalcemia is due to abnormal intracellular and extracellular distribution of calcium rather than calcium deficiency, so intravenous calcium may increase calcium influx, leading to intracellular calcium overload and causing cell function and structural damage... In cases of intravenous calcium administration, nimodipine improves the abnormal distribution of intracellular and extracellular calcium ions, resulting in increased blood calcium levels; thus, the need for calcium supplementation requires further study. During the process of using nimodipine, no side effects such as hypotension were observed, suggesting that the application of Niger lay horizon for fluoroacetamide poisoning is safe. Therefore, we believe that Niger lay horizon has clinical value in preventing and treating hypocalcemia caused by fluoroacetamide poisoning and controlling calcium influx-induced damage to brain cells, and should be widely applied.