Weifu Capsule Acute and Chronic Toxicity Experimental Study
Medium: Wu Xiaodong (1971), female (Han nationality), Haicheng City, Liaoning Province. Assistant Professor, undergraduate institute of saline dilution (per 10 tablets in 10 II ll saline). Healthy mice without trauma, 20 Kunming mice, weight 18-22g, male and female half, from Jilin University Experimental Animal Center, for the acute toxicity experiment. 40 healthy Wistar rats, weighing 100 - 120g, male and female half, from Jilin University Experimental Animal Center for drugs, chronic toxicity test.
1.2 Methods
1.2.1 Acute Toxicity Experiment... Fasted mice (normal water) after 12h, each mouse gastric perfusion has been diluted liquid 0.6ml, interval 4H again with the law administration, daily dose was 2.4 L1 (considerable clinical patients daily volume 105 times), continuous after administration of 7D was observed in mice with and without symptoms of poisoning and death, were sacrificed after anatomy and the important organ for histopathological examination.
1.2.2 Chronic Toxicity Test Randomly divided 40 rats into 4 groups, namely, control of second male experimental period of the Wu Xiaodong, and so on. Weifu Capsule on acute and chronic toxicity experimental study of a 67 group, control group and female experiment, each group of l0 rats. The experimental group of each rat gavage daily for dilute liquid 2.0ml, free diet; a control group of normal feed. 30d observation of an animal’s general performance, blood routine and blood biochemical index test, rats were sacrificed after taking the liver, north face sale, kidney, stomach tissue biopsy.
2 Results
2.1 Acute Toxicity Experiment Results Mice after administration of 7D survived, free activities, smooth hair, normal diet, respiratory, ocular and oral and no abnormal secretions, weight increase, not found that symptoms of poisoning and death; anatomy of the mouse, moncler france, extract the main organs were observed macroscopically and microscopically, were not found significant histopathological change.
2.2 The Result of Chronic Toxicity Experiment Rat gastric perfusion after administration of 30d survived, free activities, smooth hair, normal diet, respiratory, Moncler Türiye Outlet, ocular and oral and no abnormal secretions, weight has increased, there is no evidence of any symptoms of poisoning. Rats in each group were taken blood routine and blood biochemical indexes of detection, the results shown in Table 1 - 2; executed after taking liver, kidney, stomach and other organs of the gross and microscopic histopathological observation, abnormalities were found.
Table 1 Weifu Capsule on Rat WBC Effect (tooth)
Table 2 Weifu Capsule on Rat Biochemical Test Results Influence (tooth ± s)
Discussion:
Weifu capsule, using ginseng as Qi drug, to reinforce the temper, Qi as the main role, can eliminate or improving the deficiency of Qi, used to treat loss of appetite, moncler jacken, burnout, loose stools, thoracic abdominal distension etc. Atractylodes macrocephala for Qi drug, used to treat weak spleen and stomach, eat less abdominal distention, fatigue, diarrhea stool pond etc.. Amomum villosum for regulating qi, spleen, spleen stomach qi stagnation, moncler, with flatulence, nausea and vomiting; warming spleen stomach deficiency treatment pain, abdominal pain, diarrhea and other. Cyperus for regulating qi, regulating liver qi stagnation syndrome, treatment, see flatulence distention, abdominal pain, loss of appetite and so on. Tuckahoe is light permeability and water delivery, and Spares, treating spleen deficiency and dampness Sheng, eat less, such as diarrhea, often with dangshen, Baizhu Jianpi role for enhanced. Citrus aurantium for regulating qi, gas purge, cure indigestion caused by constipation and other. Banksia rose for regulating qi, qi stagnation pain, gastrointestinal administration with abdomen distending pain, vomiting, or food stagnation; Jianweixiaoshi, treating weakness of the spleen and stomach, eat less loose stools. Pinellia tuber for temperature of cold phlegm drugs, Jiangni vomiting, treat cold drink.