Lightbox v2.0 - Originally designed to display images, it uses Prototype and Scriptaculous, so it's a bit heavy, but works well for images.
The drawback is that when the popup layer appears, scrolling the mouse wheel causes both the parent page and the popup content to scroll simultaneously. The popup layer can only be closed by clicking the close button, which can lead to a poor user experience, especially when the popped-up image is large, as users need to move the page to find the close button.