The story still comes from the most popular computer game, but it has gradually come to an end... Alice successfully escaped from Umbrella Corporation's strictly guarded laboratory with the help of Carlos Oliveira and L.J. However, after several live experiments, Alice found that there was a kind of new power awakening in her body, so powerful that she could not control it, making her feel scared. Time continued to move forward by three years. During this period, the living dead almost destroyed the whole world, and the earth was like it had just gone through the "end of the world". There were flying yellow sands everywhere, showing a desolate and miserable scene of decay. The lucky survivors temporarily formed an alliance, roughly composing a "survival group" of about 30 people, driving various kinds of vehicles - including school buses, ambulances, news cars and oil tankers, struggling to walk on the desert of Nevada, reaching from one destroyed city to another destroyed city, just to find food and water to maintain the lowest survival guarantee, while also avoiding trouble and the living dead.