The story still comes from the most popular computer game, but it is gradually coming to an end... Alice successfully escapes from Umbrella Corporation's tightly guarded laboratory with the help of Carlos Oliveira and L.J. However, after several live experiments, Alice discovers a new power awakening within her body, so strong that she can't control it, making her feel scared. Time continues three years later, during which time zombies almost destroy the whole world, and the earth looks like it has just gone through the "end of the world", with yellow sand flying everywhere, presenting a desolate and bleak scene of decay. The few survivors have temporarily formed an alliance, roughly making up a "survival team" of about 30 people, driving all kinds of vehicles - including school buses, ambulances, news vans, and oil tankers, struggling to walk across the desert of Nevada, moving from one destroyed city to another, just to find food and water to maintain the minimum survival guarantee, while also avoiding trouble and zombies.