The story still comes from the most popular computer game, but it is gradually coming to an end... Alice successfully escapes from Umbrella Corporation's tightly guarded laboratory with the help of Carlos Oliveira and L.J. However, after several live experiments, Alice discovers a new kind of power awakening within her body, so powerful that she cannot control it, making her feel afraid. Time continues to move forward by three years. During this period, the living dead have almost destroyed the entire world, and the Earth looks like it has just gone through the "end of the world," with sand flying everywhere, presenting a desolate and miserable scene of decay. The few survivors who manage to live form alliances, roughly forming a "survival group" of about 30 people, driving various kinds of vehicles - including school buses, ambulances, news vans, and oil tankers - struggling to walk across the desert in Nevada, moving from one ruined city to another ruined city, just to find food and water to maintain the bare minimum survival needs, while also avoiding trouble and the living dead.