The story begins with the last scene of Resident Evil 1: Alice (Milla Jovovich), who has been forcibly put into a long hibernation and finally wakes up, only to find her worst fears realized - the maniacal undead zombies are everywhere in Raccoon City. Soon, Alice realizes that during her unconscious stay at the "sleeping" period in the secret research base of the "Umbrella" chemical company, she had become an experimental subject for the scientists' study on bio-genetics, which endows her with new powers and sensitivities. It is these unfamiliar new skills that save her life.