During the Qin and Han Dynasties, Commander Wang of the Wang Family Army saved a beautiful woman named Xiaowei during a fierce battle with sand bandits in the Western Regions and brought her back to the Jiangdu王府. However, this Xiaowei was actually a "Nine Skies Beauty Fox" who had transformed into human form. Her skin must be maintained by using human hearts, so Xiaowei's invisible assistant Xiaoyi - a demon transformed from a desert lizard - kills people every few days to extract their hearts as offerings to Xiaowei, as a sign of his love for her. As a result, the city of Jiangdu falls into terror. Xiaowei also develops feelings for the brave and handsome Wang, and uses witchcraft to tempt him, wanting to replace the position of Wang's wife, Peirong. Peirong discovers Xiaowei's infatuation with her husband and senses that she is not an ordinary person, so she secretly seeks help from Pang Yong, a highly skilled wandering swordsman, and Xia Bing, a pure-hearted demon slayer, to save Wang... Thus begins a complex tale of emotions, temptation, betrayal, resistance, and life-and-death battles between humans and demons.