Many women mistakenly believe that deteriorating skin, lack of luster, dullness, loss of elasticity, and dryness are caused by the loss of collagen in the skin. In fact, the real situation is not so simple. The fundamental reason for the worsening of women's skin is the result of a combination of internal and external factors. The internal factor is premature ovarian failure, while the external factor is the loss of collagen. The internal cause is the main reason, which determines the external cause.