Why is microcirculation disorder considered the pathological basis of diabetic foot gangrene? Diabetic foot is a complication of diabetes. In its advanced stages, it can easily lead to gangrene and ulcers, making diabetic foot gangrene quite severe. If wounds do not heal, there might be a need for high amputation. Therefore, we should understand the causes of diabetic foot gangrene, which is microcirculation disorder. Now, let's invite an expert from Shanxi Yikang Peripheral Vascular Hospital to introduce this topic.
Microvascular disease is an important component of microcirculation disorders. Diabetic patients are often in a state of persistent hyperglycemia, and bacterial infections can make microvascular endothelial cell damage more pronounced. The main changes include the endothelial cell body centered around the nucleus protruding into the vascular lumen, causing the lumen to become uneven or blocked, increasing blood flow resistance, obstructing blood flow, leading to degeneration and edema of the endothelial cells, and even forming microthrombi, resulting in microvascular occlusion and microcirculation disorders. Wall damage leads to decreased tension and enhanced permeability, causing bleeding and exudation, red blood cell aggregation, and enhanced platelet adhesion ability, further leading to microcirculation disorders and reduced perfusion of local tissues and organs. This causes ischemia and hypoxia in the extremities, making the feet susceptible to infection and gangrene. Therefore, microcirculation disorders are considered the pathological basis of diabetic foot gangrene.
Why is microcirculation disorder considered the pathological basis of diabetic foot gangrene? The above is a detailed introduction by experts on why microcirculation disorder is the pathological basis of diabetic foot gangrene. We hope this helps you. For more questions, you can consult online with experts from Shanxi Yikang Peripheral Vascular Hospital. Finally, wishing you good health.
For more details, please visit the diabetic foot section of Shanxi Yikang Peripheral Vascular Hospital: http://www.sxykmgy.com/tangniaobingzu/ or consult the experts for free. The experts will provide detailed answers based on the patient's specific situation.
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