You may be predisposed to depression because of loss, a messy brain chemistry or genetic factors. Here are some physical signs and information about depression. Signs of depression are fundamental the same across individuals. We all feel down from time to time; sometimes we feel inexplicably blue and at other times we are sad because of specific events like the loss of a parent or friend. Regardless, some feelings of sadness - or melancholy - are neither permanent nor debilitating. They easily dissolve with shifts in mood. However, depression is another matter%8