Gallbladder cancer is a common malignant tumor of the biliary system, ranking 5th-6th among gastrointestinal tumors in China. It is more frequently seen in the northeastern and northwestern regions, accounting for 0.6% of general surgical diseases in Heilongjiang Province during the same period. In 2000, Zou Shengquan conducted a retrospective analysis of epidemiological data on 3922 cases of gallbladder cancer nationwide, suggesting that the occurrence of gallbladder cancer is associated with age, gender, occupation, diet, and region. The peak incidence age is 50-70 years old, with a male-to-female incidence ratio of approximately 1:1.98. Among our group of 33 cases, 54.55% were combined with gallstones, patients over 50 years old accounted for 72.73%, and the male-to-female ratio was 1:3.125. Pathologically confirmed adenocarcinoma occurred in 23 cases, representing 69.7% of all cases. Serum tumor markers appear in the patient's serum or tissue before clinical symptoms, signs, or imaging changes occur, playing an important role in cancer screening, auxiliary diagnosis, efficacy evaluation, and prognosis monitoring. CA199 is a mucin-type glycoprotein which is present at very low levels in the blood of normal individuals but increases in the serum of patients with pancreatic cancer, gastric cancer, colorectal cancer, cholangiocarcinoma, ovarian cancer, cervical cancer, etc., with the most significant increase observed in pancreatic cancer, followed by gallbladder cancer.
Since CA199 is not a specific tumor marker for gallbladder cancer and CA199 is Lewis a...