Difficult infertility and reproductive diseases online, all questions will be answered. The completely revised version of gastritis is divided into acute gastritis and chronic gastritis. There are many causes, among which Helicobacter pylori (HP) infection is the most common cause. HP is a non-invasive pathogen, but it can cause a strong inflammatory response. It directly stimulates immune cells, causing mucosal inflammation or directly stimulating epithelial cell cytokines. There is a two-way relationship between HP-associated gastritis and gastric acid secretion function. On the one hand, the secretion of gastric acid affects the number and distribution of HP residing in the gastric mucosa, and affects the severity of the mucosal inflammatory response after infection; on the other hand, HP-associated gastritis changes the gastric acid secretion function of the gastric mucosa.