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Flow Injection Analysis - online extraction spectrophotometric method for rapid determination of atropine sulfate tablets ... 2039-CieriUR-Determination of small quantities of atropine in commercial preparations by liquid chromatography with fluorescence detection, Assoc. Off. A. at Chm 1985; 68:1042-10. The Health Department of the People's Republic of China has appointed dry clay lumps for drug compilation. China and the Pharmacopoeia of the People's Republic of China. Negative five-year edition. The two are combined. Beijing: China Health Press, Pandora Jewelry Roma, 1985. n. The United States Pharmacopoeia [Convention Inc. The United States Pharmacopoeia: a. 21th Ed. 1985: S1.12. The Medicines Commission. British Pharmacopoeia. Vol. II. London: Her Majesty’s Stationery Office, 1980: 736. rI3. The side opening rear. Hungary loves to count number theory in experimental design. Journal of Applied Mathematics 1980; $: 363. RAPID FIA-SPECTROPHOTOMETRIC METHOD WITH ON-LINE EXTRACTION FOR THE CONTENT UNIFORMITY TEST OF ATROPINE SULFATE TABLETS XY Qu, CF He, ghd piastra, LJ Sun, moncler, X Wang and X Luo (Shenyan Col, ege, miu miu purse, Pharmacy · She. yan ai II ~ 15; j ph. metric method based on FIA for the content uniformity test of atropine sulfate tablets has been developed. By means of this well-designed FIA system with an online extraction device, many difficulties resulting from extraction, such as slow analytical rate, environmental pollution, moncler jackets, poor reproducibility, etc., were overcome, and the routine procedure of the official content uniformity test was tremendously simplified. Results obtained with the proposed method agree well with those obtained with the official test. Furthermore, the proposed method attained a sampling rate of 60 samples per hour, a recovery of 100%, a relative standard deviation of 0.7%, and a detection limit of 0.24 µg/mL. Uniform design proves effective to optimize complex FIA conditions, and FIA provides a new approach to test the content uniformity of pharmaceutical tablets.

Keywords: Atropine sulfate; Flow injection analysis; Content uniformity test; Uniform design