The dose and plasma concentration of lamotrigine in the treatment of epilepsy, psychomotor seizures, limitations, Ralph Lauren men's clothing, attacks, etc. Due to the liver's drug-metabolizing enzyme capacity constraints on phenytoin metabolism, it exhibits non-linear dynamic characteristics. The individual differences in its in vivo metabolism are significant, and poisoning often occurs during conventional medication use. Therefore, it is necessary to conduct blood concentration monitoring and develop an individualized treatment plan. Our hospital has been conducting therapeutic drug monitoring for many years. From 1997 to 2002, we monitored the plasma concentration of phenytoin in 130 cases/patients, and the report is as follows.
Materials and Methods: 1.1 Cases - 70 epilepsy patients, including 50 males and 20 females, aged between 2.5 years and 77 years, with an average age of (31.4 ± 18.4) years; disease duration ranging from 0.2 years to 13 years, with an average disease duration of (4.8 ± 3.8) years, using Phenytoin (PHT) alone or in combination with other antiepileptic drugs for over one month.
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