4400 people were taken by visitors from the future and returned. One year later, the world has changed a lot. Collier has closed down Arcadia Estates and his own house, building a shelter for these 4400 people instead. He also plans to open a "4400 Center", where others can delve into the lives of these 4400 individuals and uncover their secrets on their own. The public is highly curious about these 4400 people, leading to widespread rumors about their mysterious abilities. Public attitudes towards them are divided into two: one side embraces them, while the other fears them. As the 4400 strive to restart their "interrupted lives," each of them will play a crucial role in the upcoming events... events that will determine the fate of humanity.