In the second season, seven death row inmates became the targets of a nationwide manhunt and embarked on a new round of fugitive journey. They faced various situations during the escape process, so the story continued to develop. Moreover, because Lincoln was framed for being involved in a government conspiracy, from the beginning of the second season, the two brothers, Michael Scofield, focused on investigation, hoping to uncover the dark truth behind the conspiracy. And the five successful escapees fled in the central United States, among whom some would be re-arrested and others would die during the escape.