A film crew, in search of the mysterious Hilisha Na tribe, is heading into the enigmatic Amazon rainforest. Along the way, they meet a "python expert" who has lived in the forest for many years. He has been hunting a fierce and cunning giant python that is forty feet long. In order to leverage the strength of the film crew, he uses the excuse of being their guide to lead them into the territory of this giant python. And just like that, the film crew finds itself in extreme danger, completely unprepared...